The Global Overweight & Obese Person Registry (GLOBE) is an international, observational research study for adults with a body mass index (BMI) over 25.

Its purpose is to understand how carrying extra weight affects people in the real world: their physical and mental health, day-to-day life, work, and personal finances – and how different weight-management approaches perform outside clinical trials.

GLOBE is not a diet programme and not a drug trial. It is not sponsored by any pharmaceutical company. We collect data, we do not prescribe treatments.

• Most evidence used to make decisions about obesity care and funding comes from narrow populations in controlled trials.
• Many people with BMI > 25 feel existing research does not reflect their lives or challenges.
• Health services and payers need robust, patient-centred real-world evidence to design services and fund treatments fairly.
• GLOBE aims to fill these gaps with data grounded in the lived experience of people with overweight and obesity.

• 18 years or older.
• Self-identify as having a BMI > 25 (overweight or obese).
• Able to read and write English.
• Have reliable internet access and an email address.
• Willing to complete online questionnaires.

• Read an online Participant Information Sheet and provide e-consent if you agree.
• Complete a short background questionnaire.
• Complete two online surveys over roughly two months about your symptoms, quality of life and costs related to your weight.
• Total time commitment for Phase 1 is expected to be under two hours.

In some countries, you may receive a small thank-you payment or voucher after you have completed both surveys, in line with local regulations.

• It is not a diet or coaching programme.
• It is not a trial of any specific medicine (e.g. Ozempic or Mounjaro).
• You will not be asked to change your treatment as part of the study.
• We will not tell your doctor how to treat you.

We will use anonymised data from many people like you to build a clearer picture of what changes when weight is managed – not only on the scales, but in your energy, mobility, mood, work and finances.

• Clinicians or allied health professionals who regularly manage adults with BMI > 25.
• Working in primary care, endocrinology, bariatric surgery, obesity or weight-management services.
• Able to complete online surveys in English.

• Contribute to two structured online surveys.
• Identify the symptoms, signs, comorbidities and service components you see in practice.
• Prioritise which items must be captured in the final clinical and cost instruments.
• Help ensure the registry reflects real-world practice rather than guideline ideals alone.

Participants in the healthcare professional panel will receive an honorarium in line with fair-market-value rates for their specialty and country, in accordance with local regulations and institutional policies.

GLOBE is designed as a flexible platform for future research and service evaluation in overweight and obesity. We welcome collaboration with clinical centres, health systems, payers and academic partners.

GLOBE has received a favourable opinion from an NHS Research Ethics Committee. The study is conducted in accordance with the Declaration of Helsinki and applicable data-protection regulations (including GDPR where relevant).

• Participants provide informed consent before any data are collected.
• Data are stored securely on password-protected systems with restricted access.
• Each participant is assigned a study ID; names and direct identifiers are kept separate.
• Publications and presentations will only use anonymised, aggregated data.

• Participation is voluntary. You may withdraw at any time without giving a reason.
• You may skip any question you do not wish to answer.
• Some people may find questions about weight or quality of life upsetting. Support options and contact details are provided in the Participant Information Sheet.

GLOBE is an observational study only. It does not replace advice from your usual healthcare professionals. If you have concerns about your health, you should contact your doctor or local health services.

Participation in the GLOBE Registry takes place through the Medialis platform. You can access the study using a web browser on desktop or the Medialis mobile app.

1. Contact us at info@medialis.co.uk.
2. Open Medialis Insights App on your chosen device (desktop browser or mobile app).
3. Create your account using the email address provided for the research. A verification code will be sent to your email.
4. Sign in and enter your study access code to unlock the GLOBE study.
5. Complete the questionnaires, starting with Consent and Demographics. Click into the next questionnaire tile to continue.

If you cannot find the verification email, please check your spam or junk folder.